Vitamin D Level Is Directly Correlated to COVID-19 Outcome

There is strong evidence vitamin D plays a role in your immune reaction and your ability to resist infections. In this movie, chief and biochemist program officer for Irish Heart Disease Awareness, Ivor Cummins, clarifies how research may lessen your risk of negative effects.

He singles out a number of the conditions such as elevated levels of inflammation, insulin resistance and reduced sunlight exposure.

In 2017, a review of randomized, double-blind, placebo-controlled trials using vitamin D2 or D3 was printed in the BMJ.1 The data demonstrated vitamin D supplementation was”safe and it shielded against acute respiratory tract infection all around.” They discovered people who were most deficient experienced the best benefit.

I am excited to announce a revolutionary new study by an organization that we have supported for GrassRootsHealth, over 13 decades. A lot of you have ordered their vitamin D evaluation in the past, and the funds from that were used to perform this trial that could change the treatment strategy for COVID-19.

A new clinical trial to investigate the efficacy of vitamin D against COVID-19 was declared April 3, 2020.2 Days afterwards, Mark Alipio — who received no funds because of his job — printed a preprint letter3,4 in which he published data from an investigation of 212 individuals with lab-confirmed COVID-19 and for whom there were serum 25(OH)D levels out there. You are able to read Alipio’s full study here.

Using a number of symptoms based on previous research, he used statistical analysis to compare the differences in clinical outcomes against the degree of vitamin D. Of the 212 individuals, 49 had mild disorder; 59 had regular disorder; 56 were severe and 48 were crucial.

vitamin d covid-19 severity

In the first study team of 212 patients (see Table 1 below), 55 had normal vitamin D levels, which Alipio defined as larger than 30 ng/ml; 80 had inadequate levels of 21 to 29 ng/ml and 77 had deficient levels of less than 20 ng/ml. Vitamin D levels were correlated to the severity of the illness. It’s crucial to be aware that most experts consider 30 ng/ml half of what an optimum vitamin D level ought to be, which can be 60 to 80 ng/ml.

descriptive statistics

Of the 49 with mild illness, 47 had normal vitamin D levels. For all those of you who aren’t good with math that means that 96 percent of the patients with mild illness had”normal” amounts of vitamin D. Notice again this”normal” level was over 30, and most experts would increase to 60.

Of the combined 104 with illness that is severe or significant, only four had normal levels of vitamin D. That is the reciprocal of the group or 4 percent. Could one hope for? Alipio concluded:5

“… this research offers substantial information to clinicians and health policy-makers. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Covid-2019 based on increasing likelihood ratio of having a mild results when serum (OH)D level raises. Additional research may run randomized controlled trials and large population studies to evaluate this recommendation”

Additional Proof Vitamin D Significantly Impacts Outcomes

Some recent editorial in Alimentary Pharmacology & Therapeutics6’s writers used a metric that was unique, but arrived at similar results. They contended that a marked variation in mortality occurs above or below latitude. This is also the line over that it is not possible for people to get enough sunlight to retain vitamin D.

The outcomes imply vitamin D plays a part in the result of infection, when the mortality per million is plotted against latitude. Data were accumulated from countries reporting over 150 individuals infected by April 15, 2020.

Although countries are far north of the demarcation line, vitamin D deficiency is comparatively low, possibly from widespread use of nutritional supplements. In countries such as Spain and Italy, mortality rates are higher. The writers stress the significance of vitamin D to the results of infection, concluding that, while there is modest evidence, it protects against infection:7

“… the hypothesis is not that vitamin D could shield against SARS-CoV-2 infection but it might be quite crucial in preventing the cytokine storm and subsequent acute respiratory distress syndrome that’s commonly the cause of mortality.”

Another paper8 printed in April 2020 hypothesized that vitamin D protects the body against SARS-CoV-2 ailments and sought to check if there was an association between vitamin D levels and the amount of all COVID-19 infections. The data included only European countries and found that a substantial connection between the mean (average) vitamin D level and the amount of infections.9

Individuals who were most vulnerable to the respiratory infection were the most deficient. They concluded the results support the advice to supplement to protect against the SARS-CoV-2 infection. These results support the 2017 review of research mentioned above.10

Yet another paper evaluated the function vitamin D deficiency plays in preventing respiratory ailments and found similar results.11 The researchers wrote that vitamin D had”a substantial protective effect” and reduced the risk of a serious respiratory infection from 60 percent to 32 percent in participants. The researchers wrote vitamin D may help prevent ailments and lower antibiotic usage.

African-Americans Experiencing Higher Rates of Infection

A letter to the editor was subsequently printed in the BMJ, signed by 30 scientists from all over the world, such as Alipio.12 They pointed from the high number of those who are Black, Asian and Minority Ethnic (BAME), or even those living in care homes from the U.K. who die from COVID-19.

In addition they identified obesity as yet another risk factor, together with co-morbid conditions like cardiovascular disease and diabetes. Each group of people — those living in care homes, BAME and obese tends to have lower amounts of vitamin D.

The letter included the research results from Alipio’s preprint letter, indicating the 30 scientists agreed with how the data was gathered and analyzed, in addition to the decisions. The team identified the lengthy process vaccines demand and the 100 decades of research on vitamin D.

They hypothesized that vitamin D may lessen the amount of deaths and has clinical relevance to COVID-19. It’s important to notice the widespread vitamin D deficiency, including the risk groups, although there is a demand for clear clinical evidence with research. They estimate

“The lack of any nutrient that’s essential for every single tissue will eventually lead to abnormal function in every tissue. That is really incontrovertibly obvious that I’m continually astonished it has to be repeatedly forcefully restated.”

They went on to Provide a reason behind vitamins have been overlooked:14

“Human nature is such that easy solutions to complicated issues, for example vitamin C for scurvy, and hand washing before infant delivery, are usually not readily adopted; but definitely the scale and impact of this COVID-19 pandemic demands all of avenues are fully explored; more so when no other effective treatment plans as yet exist.

A safe easy step, the correction of a deficiency state, vitamin D this moment, convincingly holds out a possible, important, feasible’COVID-19 mitigation remedy.”

Others join with the heavy toll from the African-American community with an increased incidence of obesity, diabetes and high blood pressure, which can be risk factors for increased severity of COVID-19.15 In the states of Maryland and Louisiana and the metropolises of New York, Chicago and Washington, D.C., the percentages of BAME people dying from probable COVID-19 are higher than the percentages of BAME who live in the region.

But despite the fact that there is a correlation between the higher incidence of health conditions that increase disease severity from the African-American population, there is also a higher incidence of vitamin D insufficiency due to reduced production.16 atopic dermatitis generates less vitamin D with exposure to sunlight.

Vitamin D in COVID-19 Treatment

Findings from The Irish Longitudinal Study on Ageing (TILDA)17 and a vitamin D review paper18 printed in the journal Nutrients, April 2, 2020, also imply vitamin D deficiency might have severe consequences for COVID-19. According to Medical Xpress, April 6, 2020:19

“The report,20 ‘Vitamin D deficiency in Ireland — Implications for COVID-19. Outcomes from the Irish Longitudinal Study on Ageing (TILDA),’ discovers vitamin D plays a crucial role in preventing respiratory ailments, reducing antibiotic usage, and boosting the immune system reaction to infections.

With one in eight Irish adults under 50 deficient in vitamin D, the report highlights the significance of increasing ingestion … TILDA researchers recommend that adults over 50 should take nutritional supplements — not just in winter months, but all year round if they don’t get enough sun …

Professor Rose Anne Kenny, chief researcher of TILDA, stated:’We have evidence to support a role for vitamin D in the prevention of chest infections, particularly in older adults who have low levels. To half Vitamin D reduced the risk of chest ailments in 1 study.

Though we don’t know specifically of the function of vitamin D in COVID infections, given its wider implications for improving immune reactions… at-risk cohorts must ensure they have an adequate intake of vitamin D.'”

The second paper, published in the journal Nutrients, carries the telling name,”Evidence That Vitamin D Supplementation Could Decrease Risk of Influenza and COVID-19 Infections and Death. “21 As mentioned from the abstract:

“This report reviews the functions of vitamin D in reducing the risk of respiratory tract ailments, knowledge concerning the epidemiology of flu and COVID-19, and how vitamin D supplementation might be a useful step to decrease risk. Through mechanisms, vitamin D can lower risk of infections.

These mechanisms include inducing cathelicidins and defensins that may lower viral replication rates and reducing concentrations of pro-inflammatory cytokines that create the inflammation that injures the lining of their lungs, leading to pneumonia, in Addition to increasing concentrations of anti inflammatory cytokines …

Evidence supporting the role of vitamin D in reducing threat of COVID-19 includes the outbreak happened in winter months, a period when 25-hydroxyvitamin D (25(OH)D) concentrations are lowest; that the number of instances from the Southern Hemisphere near the conclusion of summer are reduced …

Vitamin D deficiency has been proven to bring about acute respiratory distress syndrome; and … case-fatality rates rise with age and with chronic illness comorbidity, both of which are correlated with lower 25(OH)D concentration.

To decrease the probability of infection, it is advisable that individuals at risk of flu and/or COVID-19 contemplate taking 10,000 IU/d of vitamin D3 to get a few weeks to quickly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal ought to be to increase 25(OH)D concentrations over 40–60 ng/mL (100–150 nmol/L). For treatment of people who become infected with COVID-19, high vitamin D3 doses might be useful.”

UK Recommends Supplementation

Public Health England is recommending their citizens choose a vitamin D supplement whenever they’re spending more time inside.22 The National Health Service23 frequently recommends their citizens choose a supplement during the fall and winter season. They also suggest a nutritional supplement all year round for those who aren’t outdoors, are in a care home, usually cover all their skin or have dark skin.

The chief nutritionist at Public Health England is worried that Britons may not be receiving enough vitamin D from sunlight since they spend more time inside. They advise their citizens that while an illness cans not prevent, it does have benefits, such as improved outcomes in those people who are deficient.24

However, despite radical changes in the way that people live during the pandemic, the principles in the U.S. haven’t changed. The National Institutes of Health recommends that the majority of people receive their nutrients such as food items. Dietary intake Isn’t sufficient to maintain healthy levels

“Dietary intake of vitamin D from organic foods traditionally plays only a minor role with few available organic resources: animal resources like fatty fish, cod liver oil, or even egg yolk contain vitamin D3, and fungal resources such as mushrooms and yeast subjected to sunlight or UV radiation contain vitamin D2 (ergocalciferol).”

The U.S. health agencies seem to have little interest in helping the public support their immune system through appropriate nutrition but would rather rely on drugs and vaccines.

Some Public Health Officials Recognize Value of Vitamin D

Some are speaking out Even though the official recommendation from government agencies would be to wait for a vaccine and drugs. Former CDC director Dr. Tom Frieden wrote a comment piece for Fox News in which he suggests vitamin D may decrease COVID-19 mortality rates, particularly in those people who are deficient.26

He goes on to state supplementation has reduced the”threat of respiratory ailments, regulates cytokine production and may limit the probability of other viruses like influenza.” Much of the damage from COVID-19 happens with a”cytokine storm,” through which the body’s inflammatory system goes into high gear, damaging organs and increasing mortality prices.

The evidence of seasonality of several infections may be linked to vitamin D production that declines during winter. Changes in infection rates are more evident in northern climates, and little or none in areas that are warm throughout the year. He concluded:27

“We can do a lot of stuff to enhance our immunity to infection. These include getting regular physical activity, getting enough sleep, stopping smoking and tobacco use, as well as for individuals living with diabetes, getting it. Taking a multivitamin that includes a Vitamin D supplement, or Vitamin D , likely can’t hurt, and it might help.

As we continue to work to mitigate the impact of COVID-19, anything we can do to strengthen our immunity is a step in the ideal direction.”

Dr. John C. Umhau is a public health specialist at the National Institutes of Health. In an article in MedPageToday he declared his review in which he contended there were groups who were more likely to have vitamin D deficiency, for example those who are obese, the elderly and people who have dark skin. Yet vitamin D is one of the:28

“most researched and most important host factor impacting survival from COVID-19… A government-sponsored research strategy to deal with this issue hasn’t yet been developed, as officials clarified that there was no mandate to research a substitute for the existing vaccination program.

However, other investigators picked the ball up and provided persuasive evidence that vitamin D could reduce the incidence of acute respiratory infection.”

In evidence printed in Nutrients,29 scientists reviewed vitamin D can reduce the chance of infection by lowering the rate at which the virus replicates and lessen the pro-inflammatory cytokines that damage the lungs, resulting in pneumonia. Vitamin D helps increase concentrations of anti inflammatory cytokines that may help protect the lungs. The investigators recommended those at risk take:

“10,000 IU/d of vitamin D3 to get a few weeks to quickly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal ought to be to increase 25(OH)D concentrations over 40–60 ng/mL (100–150 nmol/L).”

Folks Dosages Vary Widely — Evaluation To Be Sure

Although the researchers recommended a particular amount of vitamin D3 to take, it’s impossible to predict just how much supplementation you may need unless your blood level is measured. Normally, ranges are from 2,000 to 10,000 units (IUs) per day, however, there are many variables that contribute to the dose — that is the reason why testing is so vital.

Unless you’re having symptoms of a worsening respiratory infection by studying at home you may stay away from hospitals. You’d like your level to be 60 ng/mL.

GrassrootsHealth makes testing simple by offering an inexpensive vitamin D testing kit as part of its consumer-sponsored research. All earnings from these kits go to GrassrootsHealth. I make no profit from these types of kits and only provide them to my readers as a support of advantage.

To learn more regarding supporting your immune system, combating the SARS-CoV-2 virus and extra nutraceuticals that have demonstrated a positive effect on your immune system or combating viral infections, visit”Quercetin and Vitamin D — Allies Against Coronavirus?

Interesting Note on Fauci and Vitamin D

As reviewed in an earlier article, long before SARS-CoV-2 became part of normal life, Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), believed vitamin C and D were significant strategies for improving your body’s immune system. On how to avoid getting sick four decades ago, he had been interviewed by a reporter from Washingtonian.

He clarified the importance of getting enough sleep, clipping on your nails and washing your hands. A fourth strategy he spoke used vitamin D and vitamin C supplements:30

“It can boost your body’s defense against germs. I take 1,000 mg a day. Many individuals also don’t get enough vitamin D, which impacts a lot of body acts, so that might be helpful, too.”

In the current pandemic, the U.S. has placed inexpensive, patent-free supplements in 2nd place to drugs and vaccines, which come with a high price tag along with unwanted side effects.

In a interview with RealClearPolitics, Fauci seemed to hedge his opinion. He stressed the viability of vitamin C as an antioxidant that’s”essentially completely benign if you don’t take in a ridiculous amount.”

But when asked if vitamin D might mitigate some respiratory ailments, he saidthere’s”no definitive evidence.” He’d point out, however, that you’re not likely to receive hurt by it.31 However, his replies suggest an unwillingness to acknowledge vitamin D plays a proven and significant part in infectious illness.

The backpedaling on D and vitamins C of might Fauci have anything to do with the fact He serves on the Leadership Council for the Bill & Melinda Gates Foundation’s International Vaccine Action Plan? He describes his own litmus test for safety and effectiveness as being tied

“That’s why you keep hearing me over and repeatedly saying the best optimal manner is to do a randomized control trial to determine as rapidly as possible if something functions, and if it does, get it out there. If it doesn’t, get it off the table”

In what seems contradictory to this statement, Fauci said a vaccine may be published in the next 12 to 18 weeks.33 However, the conventional actions to develop a comparatively”safe” vaccine averages five decades. It begins with just two to four decades of laboratory research, followed by one to two decades of research, and then Stage II and III trials.34, I

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